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CAS号 2353-33-5英文名：5-Aza-2′-deoxycytidine含量98 %分子式 C8H12N4O4 分子量228.21介绍 Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.别名 ;2′-Deoxy-5-azacytidine 4-Ami-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one Decitabine生化机理 5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.

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